Protein Molecular Weight Markers
ABclonal Technology USP21 Rabbit pAb
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology UNC50 Rabbit pAb
Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Predicted to be located in Golgi apparatus and nuclear inner membrane. Predicted to be integral component of Golgi membrane.
ABclonal Technology C6 Rabbit pAb
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.
ABclonal Technology Cpsf4l Rabbit pAb
Predicted to be involved in pre-mRNA cleavage required for polyadenylation. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in central nervous system and retina. Orthologous to human CPSF4L (cleavage and polyadenylation specific factor 4 like).
ABclonal Technology KAT5/Tip60 Rabbit pAb
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
ABclonal Technology IGHMBP2 Rabbit pAb
This gene encodes a helicase superfamily member that binds a specific DNA sequence from the immunoglobulin mu chain switch region. Mutations in this gene lead to spinal muscle atrophy with respiratory distress type 1.
ABclonal Technology GNAT3 Rabbit pAb
Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome.
ABclonal Technology ENTPD6 Rabbit pAb
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms.
ABclonal Technology ACTR1B Rabbit pAb
This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 115 in the dynactin complex.
ABclonal Technology ESPN Rabbit pAb
This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement.
ABclonal Technology SHIP1 Rabbit pAb
This gene encodes a protein from the inositol polyphosphate-5-phosphatase (INPP5) family, containing an SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. It is expressed mainly in hematopoietic cells, where its translocation from the cytosol to the plasma membrane is regulated by tyrosine phosphorylation. At the plasma membrane, it hydrolyzes the 5 phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, influencing multiple signaling pathways. It also localizes to the nucleus, possibly participating in nuclear inositol phosphate signaling. The protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations are linked to immune system defects, cancers, and Inflammatory Bowel Diseases like Crohns and Ulcerative Colitis. Alternative splicing generates multiple transcript variants.
ABclonal Technology PATZ1 Rabbit pAb
This gene encodes a protein with an A-T hook DNA-binding motif, a POZ domain for protein interactions and transcriptional repression, and zinc fingers for DNA binding, suggesting a role as a transcriptional repressor. In small round cell sarcoma, a chromosome 22 inversion fuses this gene with EWS, forming a t(1;22)(p36.1;q12) translocation. This rearrangement joins the EWS transactivation domain with this protein’s zinc finger domain, creating a chimeric transcription factor. This fusion is an example of intra-chromosomal rearrangement. Four alternatively spliced transcript variants have been identified.
ABclonal Technology FKRP Rabbit pAb
This gene encodes a protein which is targeted to the medial Golgi apparatus and is necessary for posttranslational modification of dystroglycan. Mutations in this gene have been associated with congenital muscular dystrophy, cognitive disability, and cerebellar cysts. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
ABclonal Technology ZFP64 Rabbit pAb
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of cytokine production and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus.
ABclonal Technology PDXDC1 Rabbit pAb
Enables cadherin binding activity. Predicted to be involved in carboxylic acid metabolic process. Located in Golgi apparatus.